Immunolocalization of Gαi-3 in foetal lung fibroblasts

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Immunolocalization of Gαi-3 in foetal lung fibroblasts

The normal development of the lung is dependent on signal transduction and communication within and between cells. A major family of proteins known as guanine nucleotide regulatory proteins (G proteins) is used in translating extracellular signals into intracellular events [1–3]. In particular, the high molecular weight G proteins, which are heterotrimers composed of α, β and γ subunits, have b...

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Objective(s) Galectin-3 (Gal-3) is a member of the B-galactoside-binding lectins which is expressed in a variety of tissues and plays a role in diverse biological events, such as embryogenesis, adhesion, cellular proliferation, and apoptosis. In this study, the presence and distribution of galectin-3 (Gal-3) in the mouse testicular tissue was investigated. Materials and Methods Eight adult N...

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In previous studies we have shown that transferrin (Tf) specifically stimulates dermatan- and chondroitin-sulphate proteoglycan accumulation around lung cells, and in the extracellular matrix of lung tissue, in vitro. The aim of this study was to determine whether the gene for Tf was activated in specific lung cells during development, and whether the protein product showed evidence of associat...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 1998

ISSN: 0000-0000,0903-1936

DOI: 10.1183/09031936.98.12051137